Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study

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Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study.

OBJECTIVE To examine the association between cognitive ability in childhood and mid-life cognitive decline in the normal population. DESIGN Longitudinal, population based, birth cohort study. PARTICIPANTS 2058 men and women born in 1946. MAIN STUDY MEASURES Ability in childhood measured by AH4 and test of verbal comprehension at age 15 years. Ability in adulthood measured by the national ...

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Associations between Skeletal Growth in Childhood and Cognitive Function in Mid-Life in a 53-Year Prospective Birth Cohort Study

BACKGROUND Several studies have found that shorter stature (height and limb length) in late life is associated with dementia and cognitive impairment. The extent to which childhood environment and early life cognitive function accounts for these associations is not clear. METHODS We investigated associations of adult trunk height and leg length with cognitive function in middle age, analysing...

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Structural brain complexity and cognitive decline in late life - A longitudinal study in the Aberdeen 1936 Birth Cohort

Brain morphology and cognitive ability change with age. Gray and white matter volumes decrease markedly by the 7th decade of life when cognitive decreases first become readily detectable. As a consequence, the shape complexity of the cortical mantle may also change. The purposes of this study are to examine changes over a five year period in brain structural complexity in late life, and to inve...

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Atrial fibrillation and cognitive decline: a longitudinal cohort study.

OBJECTIVE We sought to determine whether in the absence of clinical stroke, people with atrial fibrillation experience faster cognitive decline than people without atrial fibrillation. METHODS We conducted a longitudinal analysis in the Cardiovascular Health Study, a community-based study of 5,888 men and women aged 65 years and older, enrolled in 1989/1990 or 1992/1993. Participants did not ...

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Early Life Origins Cognitive Decline: Findings in Elderly Men in the Helsinki Birth Cohort Study

OBJECTIVES To examine whether the adverse effects of slow prenatal and postnatal growth on cognitive function persist to old age and predict age related cognitive decline. DESIGN AND SETTING A longitudinal birth cohort study of men born in Helsinki, Finland 1934-44. PARTICIPANTS Nine-hundred-thirty-one men of the Helsinki Birth Cohort Study, with detailed data on growth from birth to adulth...

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ژورنال

عنوان ژورنال: BMJ

سال: 2004

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.37972.513819.ee